Hadley W. Horch
Assistant Professor of Biology and Neuroscience
Spring 2009
- Molecular Neurobiology (BIO 266)
- Neuronal Regeneration (BIO 329)
- ADVANCED INDEPENDENT STUDY (NEURO 402)
| Phone | (207) 798-4128 |
| Title | Assistant Professor |
| Department | BIOLOGY |
| 2nd Title | Assistant Professor |
| 2nd Department | NEUROSCIENCE |
| Work Location | 130E Druckenmiller Hall |
| hhorch@bowdoin.edu |
Education:
B.A., Biology Swarthmore College, 1993
PhD, Neurobiology, Duke University, 2001
Post-doctoral education, Department of Neurobiology and Behavior, Cornell University, 2001-2002
Teaching Area:
Molecular Neuroscience
Research Interests:
The Horch lab uses the cricket model system to examine the molecular neurobiological basis of a number of areas including regeneration, behavior, and development. Mainly, the lab will focus on the regeneration of interneurons in the auditory system of the cricket. Removing one ear induces auditory interneurons to sprout new dendrites, grow abnormally across the mid-line, and form synapses with intact auditory neurons from the opposite ear, both in developing as well as adult crickets. This is one of the most elegant and complex examples of neuronal regeneration known. Techniques such as dextran backfills, immunohistochemistry, and confocal microscopy will be used to understand the molecular cues involved in this phenomenon. Other projects include examining the role of octopamine on male cricket aggression and attempting to create transgenic crickets in order to examine the development of individual neurons.
Recent Publications:
Horch, H.W. 2004. Local effects of BDNF on dendritic growth. Reviews in the Neurosciences, 15: 116-129.
Horch, H.W. and Katz, L.C. 2002. BDNF release from single cells elicits local dendritic growth in nearby neurons. Nature Neuroscience, 5: 1177-1184.
Horch, H.W., Kruttgen, A., Portbury, S.D, and Katz, L.C. 1999. Destabilization of cortical dendrites and spines by BDNF. Neuron, 23: 353-364.
Horch, H.W., and Sargent, P.B. 1996. Effects of denervation on acetylcholine receptor clusters on frog cardiac ganglion neurons as revealed by quantitative laser scanning confocal microscopy. J. Neurosci. 16(5): 1720-1729.
Horch, H.W., and Sargent, P.B. 1996. Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion. J. Neurocytol. 25: 67-77.
Horch, H.W., and Sargent, P.B. 1995. Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion. J. Neurosci. 15(12): 7778-7795.
Hadley's other interests:
Hadley enjoys flying, playing soccer, and wants to learn how to sea kayak.