Wiliam Jackman

Associate Professor of Biology

Teaching this semester

BIOL 2175. Developmental Biology

An examination of current concepts of embryonic development, with an emphasis on experimental design. Topics include cell fate specification, morphogenetic movements, cell signaling, differential gene expression and regulation, organogenesis, and the evolutionary context of model systems. Project-oriented laboratory work emphasizes experimental methods. Lectures and three hours of laboratory per week.

My research investigates the genetic control of vertebrate embryonic tooth development. In particular we study how cell signaling controls cellular behaviours such as proliferation during tooth organogenesis. We use zebrafish and a variety of other fish species as models in this research because we are also interested in how developmental mechanisms have changed during evolution.

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Jackman Publicationsjournal cover for Developmental Dynamics

Jeffrey C. Yu*, Zachary D. Fox*, James L. Crimp*, Hana E. Littleford*, Andrea L. Jowdry, and William R. Jackman. (2015). Hedgehog signaling regulates dental papilla formation and tooth size during zebrafish odontogenesis. Developmental Dynamics 244, 577-590. doi:10.1002/DVDY.24258

William R. Jackman, Shelby H. Davies*, David B. Lyons*, Caitlin K. Stauder*, Benjamin R. Denton-Schneider*, Andrea Jowdry, Sharon R. Aigler, Scott A. Vogel*, and David W. Stock. (2013) Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. Evolution and Development 15:2, 107-118. doi:10.1111/ede.12021

Pawat Seritrakul*, Eric Samarut, Tenzing TS Lama*, Yann Gibert, Vincent Laudet, and William R Jackman. (2012) Retinoic acid expands the evolutionarily reduced dentition of zebrafish. The FASEB Journal 26, 5014-5024. doi:10.1096/fj.12-209304

William R. Jackman, James J. Yoo*, and David W. Stock. (2010). Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Developmental Biology 10:119, doi:10.1186/1471-213X-10-119

Yann Gibert, Laure Bernard, Melanie Debiais-Thibaud, Franck Bourrat, Jean-Stephane Joly, Karen Pottin, Axel Meyer, Sylvie Retaux, David W. Stock, William R. Jackman, Pawat Seritrakul*, Gerrit Begemann and Vincent Laudet. (2010). Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling. The FASEB Journal 24, 3298-3309, doi:10.1096/fj.09-147488

Yoshiyuki Yamamoto, Mardi S. Byerly, William R. Jackman, and William R. Jeffery. (2009). Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolution. Developmental Biology 330, 200-211, doi:10.1016/j.ydbio.2009.03.003

William R. Jackman and David W. Stock. (2006). Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite organ loss. Proceedings of the National Academy of Sciences of the USA 103, 19390-19395.

David W. Stock, William R. Jackman, and Josh Trapani. (2006). Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes. Development 133, 3127-3137.

William R. Jackman, Bruce W. Draper, and David W. Stock. (2004). FGF signaling is required for zebrafish tooth development. Developmental Biology 274, 139-157.

William R. Jackman, Jolee M. Mougey*, Georgia D. Panopoulou, and Charles B. Kimmel. (2004). crabp and maf highlight the novelty of the amphioxus club-shaped gland. Acta Zoologica (Stockholm) 85, 91-99.

William R. Jackman and Charles B. Kimmel. (2002). Coincident iterated gene expression in the amphioxus neural tube. Evolution and Development 4, 366-374.

Lisa Maves, William R. Jackman, and Charles B. Kimmel. (2002). FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development 129, 3825-3837.

William R. Jackman, James A. Langeland, and Charles B. Kimmel. (2000). islet reveals segmentation in the amphioxus hindbrain homolog. Developmental Biology 220, 16-26.

James A. Langeland, Jill M. Tomsa*, William R. Jackman Jr., and Charles B. Kimmel. (1998). An amphioxus snail gene: Expression in paraxial mesoderm and neural plate suggests a conserved role in patterning the chordate embryo. Development Genes and Evolution 208, 569–577.

Timothy Quinn and William R. Jackman*. (1994). Influence of diet on detection of fecal bile acids by thin-later chromatography. Journal of Wildlife Management. 58:295-299.

*undergraduate co-author


  • B.S., University of Washington
  • Ph.D., University of Oregon
  • Postdoc, University of Colorado Boulder