Jack Bateman

Samuel S. Butcher Associate Professor in the Natural Sciences

Teaching this semester

BIOL 2112. Genetics and Molecular Biology

Jack Bateman
Integrated coverage of organismic and molecular levels of genetic systems. Topics include modes of inheritance, the structure and function of chromosomes, the mechanisms and control of gene expression, recombination, mutagenesis, techniques of molecular biology, and human genetic variation. Laboratory sessions are scheduled.

My lab studies how chromosomes are organized within the three-dimensional space of the nucleus, and, in particular, how physical interactions between chromosomes can influence gene expression. We focus on Drosophila melanogaster in part because of the amazing genetic tools available, and in part because there is extensive pairing between homologous chromosomes in this system, providing us with a simple model to study interchromosomal interactions. Some of our projects branch out into the development of new genetic technologies and resources for the Drosophila research community, and we have recently become interested in functions of non-coding DNA (in collaboration with the Palopoli lab).

Education

  • Postdoctoral Fellow, Department of Genetics, Harvard Medical School
  • Ph.D. in Cellular and Developmental Biology, Department of Cell Biology, Harvard Medical School
  • B.Sc. in Biology, Dalhousie University

Publications

Bateman, J.R., Johnson, J.E., Locke, M.N.*. 2012. Comparing enhancer action in cis and in trans. Genetics 191: 1143-1155.

Bateman, J.R.,1 Larschan, E.,1 D’Souza, R., Marshall, L.S.*, Dempsey, K.E.*, Johnson, J.E., Mellone, B.G., and Kuroda, M.I. 2012. A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila. G3: Genes, Genomes, Genetics. 2: 731-740. (1equal contribution)

Sun, F.F.*, Johnson, J.E., Zeidler, M.P., and Bateman, J.R. 2012. Simplified insertion of transgenes onto balancer chromosomes via recombinase-mediated cassette exhange. G3: Genes, Genomes, Genetics. 2: 551-553.

Griffin, R., Sustar, A., Bonvin, M., Binari, R., del Valle Rodriguez, A., Hohl, A.M., Bateman, J.R., Villalta, C., Heffern, E., Grunwald, D., Bakal, C., Desplan, C., Schubiger, G., Wu, C.T., Perrimon, N. 2009. The twin spot generator for differential Drosophila lineage analysis. Nature Methods 6: 600-602.

Bateman, J.R., and Wu, C.-t. 2008. A genomewide survey argues that every zygotic gene product is dispensable for the initiation of somatic homolog pairing in Drosophila. Genetics 180: 1329-1342. (Featured in Issue Highlights).

Bateman, J.R., and Wu. C.-t. 2008. A simple polymerase chain reaction-based method for the construction of RMCE donor vectors. Genetics 180: 1763-1766.