James Stacy Coles Professor of Natural Sciences
Cleaveland Hall - 156
A study of scientific principles that underlie chemical, instrumental, and some biological techniques used in criminal investigations by forensic scientists. Focuses on understanding materials at an atomic or molecular level to learn how forensic chemistry is used to make qualitative and quantitative measurements key to forensic investigations. Makes use of case studies and the study of specific chemical, physical, and spectroscopic techniques used in forensic investigations. Assumes no background in science. Students take part in three to four laboratory experiences. Not open to students who have credit for a chemistry course numbered 1100 or higher or to students who have credit for Mathematics 1300, Psychology 2520, or Economics 2557.
The second course in a two-semester introductory college chemistry sequence. Introduction to chemical bonding and intermolecular forces, characterization of chemical systems at equilibrium and spontaneous processes, the rates of chemical reactions, and special topics. Lectures, review sessions, and four hours of laboratory work per week. Students who have taken Chemistry 1109 may not take Chemistry 1102 for credit.
Analytical chemistry, gas-phase negative ion-molecule reactions, electron capture negative ion mass spectometry and the analysis of organic pollutants.
(* indicates an undergraduate coauthor)
ynthesis and Optical Spectroscopy of Oligo(1,6-Heptadiynes) with a Single Structures and Terminal Methylene Groups Prepared Using Adamantylimido-based: Molybdenum Wittig and Metathesis Chemistry" Journal of the American Chemical Society, in press.
E. A. Stemmler, E. A. Bruns*, C. R. Cashman*, P. S. Dickinson, and A. E. Christie, "Molecular and mass spectral identification of the broadly conserved decapod crustacean neuropeptide pQIRYHQCYFNPISCF: The first PISCF-allatostatin (Manduca sexta- or C-type allatostatin) from a non-insect" General and Comparative Endocrinology, in press.
P. S. Dickinson, T. Wiwatpanit*, E. R. Gabranski*, R. J. Ackerman*, J. S. Stevens*, C. R. Cashman*, E. A. Stemmler and A. E. Christie, "Identification of SYWKQCAFNAVSCFamide: a broadly conserved crustacean C-type allatostatin-like peptide with both neuromodulatory and cardioactive properties", Journal of Experimental Biology, 212, 1140-1152 (2009).
J. Lichter, S. Billings, A. C. Finzi, D. Gaindh*, R. B. Jackson, R. Ryals, E. A. Stemmler, S. Ziegler, W. H. Schlesinger, "Forest soil carbon dynamics under elevated CO2: Soil carbon sequestration in a pine forest after nine years of atmospheric CO2 enrichment", Global Change Biology, 14, 2910-2922 (2008).
P. S. Dickinson, E. A. Stemmler, E. E. Barton*, C. R. Cashman*, N. P. Gardner*, S. Rus*, H. R. Brennan*, T. S. McClintock, A. E. Christie "Molecular, mass spectral, and physiological analyses of orcokinins and orcokinin precursor-related peptides in the American Lobster Homarus americanus and red swamp crayfish Procambarus clarkii", Peptides, 30, 297-317 (2009).
A. E. Christie, C. R. Cashman, C. M. Smith, K. M. Beale, E. A. Stemmler, D. W. Towle, P. S. Dickinson, "Identification and characterization of a Homarus americanus tachykinin-related peptide (TRP)-encoding cDNA: genetic confirmation of the TRPs APSGFLGMRamide and TPSGFLGMRamide in the American Lobster", Peptides, 29, 1909-1918 (2008).
P. S. Dickinson, E.A. Stemmler, A. Christie, "The pyloric neural circuit of the herbivorous crab Pugettia producta shows limited sensitivity to many neuromodulators that elicit robust effects from this system in more opportunistically feeding decapods", Journal of Experimental Biology, 211, 1434-1447 (2008).
P. S. Dickinson, E.A. Stemmler, C. Cashman*, H. Brennan*, B. Dennison*, K. Huber*, B. Peguero*, W. Rabacal*, C. Goiney, C. Smith, D. Towle, A. E. Christie, "SIFamide peptides in clawed lobsters and freshwater crayfish (Crustacea, Decapoda, Astacidea): A combined molecular, mass spectrometric and electrophysiological investigation", General and Comparative Endocrinology, 156, 347-360 (2008).
A.E. Christie, C.R. Cashman*, H.R. Brennan*, M. Mingming, G. Sousa, L.J. Li, E.A. Stemmler, P.S. Dickinson, "Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags", General and Comparative Endocrinology, 156, 246-264 (2008).
Y.A. Hsu, E.A. Stemmler, D. Messinger, P. S. Dickinson, A. E. Christie, H. de la Iglesia, "Cloning and differential expression of two β-pigment dispersing hormone (β -PDH) isoforms in the crab Cancer productus: Evidence for authentic β -PDH as a local neurotransmitter and β -PDH II as a humoral factor", The Journal of Comparative Neurology, 508, 197-211 (2008).
E.A. Stemmler, C.R. Cashman*, D.I. Messinger, N.P. Gardner*, P.S. Dickinson, A.E. Christie, "High resolution direct-tissue MALDI-FTMS reveals broad conservation of three neuropeptides (APSGFLGMRamide, GYRKPPFNGSIFamide and pQDLDHVFLRFamide) across members of seven decapod crustaean infraorders", Peptides, 28, 2104-2115 (2007).
E.A. Stemmler, Y. A Hsu, C. R. Cashman*, D. I. Messinger, H. O. de la Iglesia, P. S. Dickinson, A. E. Christie, "Direct tissue MALDI-FTMS profiling of individual Cancer productus sinus glands reveals that one of three distinct combinations of crustacean hyperglycemic hormone precursor-related peptide (CPRP) isoforms are present in individual crabs", General and Comparative Endocrinology, 154, 187-192 (2007).
E. A. Stemmler, E.A. Bruns*, N.P. Gardner*, P. S. Dickinson and A.E. Christie, "Mass spectrometric identification of : a crustacean peptide hormone possessing a vertebrate neuropeptide Y (NPY)-like carboxy-terminus", General and Comparative Endocrinology, 152, 1-7 (2007).
E. A. Stemmler, B. Peguero*, E.A. Bruns*, P. S. Dickinson and A.E. Christie, "Identification, physiological actions, and distribution of TPSGFLGMRamide: a novel tachykinin-related peptide from the midgut and stomatogastric nervous system of Cancer crabs", Journal of Neurochemistry, 101, 1351-1366 (2007).
A. E. Christie, K. K. Kutz-Naber, E. A. Stemmler, A. Klein, D. I. Messinger, C. C. Goiney, A. J. Conterato*, Emily A. Bruns*, Y. A. Hsu, L. Li, P. S. Dickinson, "Midgut epithelial endocrine cells are a rich source of the neuropeptides APSGFLGMRamide (Cancer borealis tachykinin-related peptide Ia) and GYRKPPFNGSIFamide (Gly1-SIFamide) in the crabs Cancer borealis, Cancer magister and Cancer productus", Journal of Experimental Biology, 210, 699-714 (2007).
E.A. Stemmler, N.P. Gardner* M. E. Guiney*, E.A. Bruns*, P.S. Dickinson, "The Detection of Red Pigment Concentrating Hormone (RPCH) in Crustacean Eyestalk Tissues using Matrix Assisted Laser Desorption/Ionization-Fourier Transform Mass Spectrometry: [M+Na]+ Ion Formation in Dried Droplet Tissue Preparations", Journal of Mass Spectrometry, 41, 295-311 (2006).
A. E. Christie, E.A. Stemmler, B. Peguero*, D.I. Messinger, H.L. Provencher*, P. Scheerlinck*, Y. A. Hsu, M. E. Guiney*, H.O. de la Iglesia, P. S. Dickinson, “Identification, Physiological Actions and Distribution of VYRKPPFNGSIFamide (Val1-SIFamide) in the Stomatogastric Nervous System of the AmericanLobster Homarus americanus” , Journal of Comparative Neurology, 496, 406-421 (2006).
A. E. McBride, J. T. Cook*, E. A. Stemmler, K. L. Rutledge, K. A. McGrath*, J. A. Rubens*, “Arginine methylation of yeast mRNA-binding protein Npl3 directly affects its function, nuclear export and intranuclear protein interactions”, Journal of Biological Chemistry, 280, 30888-30898 (2005).
E.A. Stemmler, H.L. Provencher*, M. E. Guiney*, N.P. Gardner*, P.S. Dickinson, “Matrix Assisted Laser Desorption/Ionization-Fourier Transform Mass Spectrometry for the Identification of Orcokinin Neuropeptides in Crustaceans using Metastable Decay and Sustained Off-Resonance Irradiation”, Analytical Chemistry, 77, 3594-3606 (2005).
J. Lichter, S. H. Barron*, C. E. Bevacqua*, A. C. Finzi, K. F. Irving*, E. A. Stemmler, and W. H. Schlesinger, “Soil carbon sequestration and turnover in a pine forest after six years of atmospheric CO2 enrichment”, Ecology, 86, 1835-1847 (2005).
E.A. Stemmler. Book review: “Analytical Mass Spectrometry. Strategies for Environmental and Related Applications” by William L. Budde. Journal of the American Chemical Society 124, 12627-12628 (2002).
E.A. Stemmler and C. Segovis* "Formation of · CH2OC(O-)CR2 Distonic Radical Anions by the Reaction of O-. with Dimethyl Glutarates", Journal of Mass Spectrometry, 36, 685-688 (2001).
E.A. Stemmler, E. Yoshida*, J. Pacheco*, J. Brunton*, E. Woodbury*, and T. Solouki. "The Reactions of O-. with Methyl Benzoate: An NICI and FT-ICR Study", Journal of the American Society of Mass Spectrometry, 12, 694-706 (2001).
E.A. Stemmler, "Mass Spectrometry", in Microscale Organic Laboratory , 4th ed.; D.W. Mayo, R.M Pike, P.K. Trumper, John Wiley&Sons, New York, 1999; pp 600-617.
R. L. Hettich and E.A. Stemmler, "Investigation of Oligonucleotide Fragmentation with Matrix-assisted Laser Desorption/Ionization Fourier-transform Mass Spectrometry and Sustained Off-resonance Irradiation", Rapid Communications in Mass Spectrometry, 10, 321-327 (1996).
E. A. Stemmler, G. B. Hurst, M. V. Buchanan, and R. L. Hettich, "The Analysis of Modified Oligonucleotides By Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry", Analytical Chemistry, 67, 2924-2930 (1995).
E. A. Stemmler, "Oxygen-18 Incorporation in NICI Mass Spectrometry: The Role of O2, H2O, and Rhenium Oxides in Surface-Assisted Oxidation Reactions", International Journal of Mass Spectrometry and Ion Processes, 142, 177-193 (1995).
E. A. Stemmler, J.L. Diener*, and J. A. Swift*, "Gas-Phase Reactions of O2-. with Alkyl and Aryl Esters of Benzenedicarboxylic Acids", Journal of the American Society of Mass Spectrometry, 5, 990-1000 (1994).