Location: Bowdoin / Calendar


Weekly Chemistry Seminar, David Forbes, University of South Alabama

  • 3/1/2013 | 3:00 PM – 4:00 PM
  • Location: Druckenmiller Hall, Room 020
  • Event Type: Seminar

Weekly Chemistry Seminar, David Forbes, University of South AlabamaReaction of sulfur ylide with aldehyde, imine, and ketone functionality affords the desired three-membered heterocycle in excellent yield. The sulfur ylide is generated in situ upon decarboxylation of carboxymethylsulfonium betaine functionality. Of the carboxymethylsulfonium betaine derivatives surveyed, the highest level of conversion of p-acceptor to heterocycle was obtained with the one having S-methyl and S-phenyl functionality bound to a thioacetate derivative. Methylene aziridinations and epoxidations involving the decarboxylation of carboxymethylsulfonium betaine functionality complements existing technologies with the advantages of the reaction protocol, levels of conversion, and scope. Presented will be our approach and application of methylene transfers using sulfur ylide technologies