Samuel S. Butcher Associate Professor in the Natural Sciences
Druckenmiller Hall - 230C
The first in a two-semester introductory biology sequence. Topics include fundamental principles of cellular and molecular biology with an emphasis on providing a problem-solving approach to an understanding of genes, RNA, proteins, and cell structure and communication. Focuses on developing quantitative skills, as well as critical thinking and problem solving skills. Lecture and weekly laboratory/discussion groups. To ensure proper placement, students must take the biology placement examination and must be recommended for placement in Biology 1101. Students continuing in biology will take Biology 1102 , not Biology 1109 , as their next biology course.
A seminar exploring the complex relationship between genotype and phenotype, with an emphasis on emerging studies of lesser-known mechanisms of inheritance and gene regulation. Topics include dosage compensation, parental imprinting, paramutation, random monoallelic expression, gene regulation by small RNAs, DNA elimination, copy number polymorphism, and prions. Reading and discussion of articles from the primary literature.
My lab studies how chromosomes are organized within the three-dimensional space of the nucleus, and, in particular, how physical interactions between chromosomes can influence gene expression. We focus on Drosophila melanogaster in part because of the amazing genetic tools available, and in part because there is extensive pairing between homologous chromosomes in this system, providing us with a simple model to study interchromosomal interactions. Some of our projects branch out into the development of new genetic technologies and resources for the Drosophila research community, and we have recently become interested in functions of non-coding DNA (in collaboration with the Palopoli lab).
Bateman, J.R., Johnson, J.E., Locke, M.N.*. 2012. Comparing enhancer action in cis and in trans. Genetics 191: 1143-1155.
Bateman, J.R.,1 Larschan, E.,1 D’Souza, R., Marshall, L.S.*, Dempsey, K.E.*, Johnson, J.E., Mellone, B.G., and Kuroda, M.I. 2012. A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila. G3: Genes, Genomes, Genetics. 2: 731-740. (1equal contribution)
Sun, F.F.*, Johnson, J.E., Zeidler, M.P., and Bateman, J.R. 2012. Simplified insertion of transgenes onto balancer chromosomes via recombinase-mediated cassette exhange. G3: Genes, Genomes, Genetics. 2: 551-553.
Griffin, R., Sustar, A., Bonvin, M., Binari, R., del Valle Rodriguez, A., Hohl, A.M., Bateman, J.R., Villalta, C., Heffern, E., Grunwald, D., Bakal, C., Desplan, C., Schubiger, G., Wu, C.T., Perrimon, N. 2009. The twin spot generator for differential Drosophila lineage analysis. Nature Methods 6: 600-602.
Bateman, J.R., and Wu, C.-t. 2008. A genomewide survey argues that every zygotic gene product is dispensable for the initiation of somatic homolog pairing in Drosophila. Genetics 180: 1329-1342. (Featured in Issue Highlights).
Bateman, J.R., and Wu. C.-t. 2008. A simple polymerase chain reaction-based method for the construction of RMCE donor vectors. Genetics 180: 1763-1766.