Upcoming Events

Jimmy Wu, Chemistry Department Seminar: "Total Synthesis and Biological Evaluation of Several Nuphar Alkaloids and their Derivatives"

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September 11, 2015 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

The hydroxylated dimeric nuphar alkaloids are found in the common yellow water lily. In particular, 6-hydroxythiobinupharidine has been shown to induce apoptosis in human leukemia cell lines (U937) faster than any known small molecule. However, the only two studies concerning their biological mechanism of action are inconclusive. The first synthesis of any dimeric Nuphar alkaloids was reported in 2013, but was of an inactive compound. This lecture will describe our work in carrying out the first total syntheses of the biologically active hydroxylated nuphar alkaloids.4 We also report new apoptosis data on several other compounds, including unnatural monomeric analogs previously unknown

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Chemistry Department Seminar Andrew Parsons. Amgen Boston Massachusettes

September 25, 2015 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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Chemistry Department Seminar Scott Bearman. Colorado Blood Cancer Institute "BMT 101. An Introduction to Blood and Marrow Transplantation".

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October 2, 2015 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

Stem cells have the capacity to self-replicate as well as differentiate into more mature cell types.  Hematopoietic stem cells reside in the bone marrow and differentiate into mature blood cells with the capacity to carry oxygen, fight infection, and stop bleeding.  The transplantation of hematopoietic stem cells has been used for more than 60 years to treat disorders where the marrow fails to produce normal mature blood cells, such as severe aplastic anemia, and various cancers of the blood and immune systems, such as leukemias and lymphomas.  Transplantation of hematopoietic stem cells permits replacement of abnormal or malignant cells and supports the ability to use doses of chemotherapy or total body irradiation that would otherwise be lethal to the bone marrow.    This talk will review the distribution of hematopoietic stem cells in the body, describe how those cells are collected, and discuss how they are used to treat selected diseases.  Some of the first reports using hematopoietic stem cells will be presented.  Practical considerations in taking care of patients undergoing stem cell transplantation will also be discussed, such as selection of suitable donors, the use of immunosuppression to minimize graft rejection and graft-vs-host disease, and the potential infectious complications of which these patients are at risk.   Anticipated growth in this field and new directions in cell based therapies for blood cancers will also be described.

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Presidents Science Symposium Dr. Chad Mirkin Northwestern University

October 23, 2015 9:00 AM  – 6:00 PM
Morrell Gym, Gymnasium

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Chemistry Department Seminar Lisa Marcaurelle H3 Biomedicine Inc. Cambridge MA

November 13, 2015 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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Chemistry Seminar Terry Gullion West Virginia University

February 5, 2016 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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Chemistry Seminars Marilyn Gunner. City College of New York

February 19, 2016 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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Chemistry Department Seminar- Michael Boyce. Duke University

April 8, 2016 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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Chemistry Department Seminar- George O Toole Geisel School Of Medicine At Dartmouth

April 29, 2016 3:00 PM  – 4:00 PM
Druckenmiller Hall, Room 020

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