Nicole A. Theodosiou

Assistant Research Professor of Biology

Phone (207) 725-3983
Title Assistant Research Professor
Department BIOLOGY
Work Location 120B Druckenmiller Hall
Nicole A. Theodosiou

Assistant Research Professor of Biology

View Previous Courses

Fall 2004 Courses
  • Developmental Biology (bio217)
Fall 2003 Courses
  • Developmental Biology (bio217)

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Contact Information

Phone(207) 725-3983
TitleAssistant Research Professor
Work Location120D Druckenmiller Hall


B.A., Biology, Swarthmore College
Ph.D., Genetics, Yale University
Post-Doctoral Research Fellow, Department of Genetics, Harvard Medical School, Tabin Lab

Research Interests

In my laboratory, we use the chick embryo system to study patterning of the developing gastrointestinal tract. The developing gut tube is an excellent system for studying basic concepts in developmental biology: morphogenesis, differentiation, tissue-tissue interactions and axis formation. The primitive gut tube is composed of two tissues: a luminal lining of endoderm-derived epithelium surrounded by an outer layer of splanchnic mesoderm. As developmental progresses, regional specification of the epithlium along the anterior-posterior axis is coordinated by communication between the mesoderm and endoderm layers along the radial axis, to define each organ and determine its specialized function in the digestive tract. While many of the tissue interactions which direct gut organogenesis have been defined, the molecular nature of the signals responsible for these inductive events are only starting to be elucidated. In addition, my lab is taking an evolution/development approach to gut patterning using the skate (Leucoraja erinacea) as a model system.

chicken biological diagram

Recent Publications

Theodosiou, N.A., and Tabin, C.J.(2005) Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signaling . Developmental Biology 279: 481-490.

Theodosiou, N.A., and Tabin, C.J.(2003) Wnt signaling during development of the gastrointestinal tract. Developmental Biology 259: 258-271.

Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM. (2000). Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evol Dev 2:348-359.

Rooke, J.E., Theodosiou, N.A. and Xu, T. (2000). Clonal analysis in the examination of gene function in Drosophila. Methods in Molecular Biology 137: Developmental Biology Protocols III, 15-22.

Theodosiou, N. A., Zhang, S., Wang, W. Y., and Xu, T. (1998). slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development, 125, 3411-3416.

Theodosiou, N.A. and Xu, T. (1998). Use of the FLP-FRT system to study Drosophila development. Methods, 14,335-365.

Theodosiou Lab Resources