Olins' Scientific Interests

Ada and Donald Olins
Ada L. Olins Donald E. Olins
Biology Department
6500 College Station
Bowdoin College
Brunswick,ME 04011
email for Ada: aolins@bowdoin.edu
email for Don: dolins@bowdoin.edu

CHROMATIN AND NUCLEAR STRUCTURE

A fanciful view of chromatin structure
A fanciful view of chromatin structure. "Le pont des planetes" in J. J. Grandville’s Un Autre Monde (1844). Paris: H. Fournier

Research Interests.

Our laboratory is focused on understanding the structural organization of chromatin and chromosomes within the interphase nucleus. Over the years we have studied a variety of eukaryotic cells that possess advantages for the analysis of structure, employing microscopy (light and electron), biochemical and immunochemical techniques. Our initial description of the fundamental repeating chromatin subunit (nucleosome) was performed principally on nuclei from avian erythrocytes, which contain large amounts of transcriptionally inactive chromatin. Later we devoted considerable study to the 3-D architecture of the Balbiani Ring, the enlarged transcriptionally active region of polytene chromosomes in the salivary gland of the midge Chironomus tentans. Simultaneously we performed investigations of the Replication Band (the migrating factory of DNA and chromatin replication) within the macronucleus of the ciliated protozoan Euplotes eurystomus. Recently we have turned our attention to the development of the lobulated nuclear shape of neutrophil granulocytes in the blood of mouse and man. We have demonstrated that changes in the composition of the nuclear envelope during granulopoiesis, particularly the presence of sufficient lamin B receptor (LBR), are necessary for the acquisition of the normal lobulated nuclear shape. The goals of our present studies are to understand the mechanism of nuclear lobulation, the roles of LBR and lamins and the influence of cytoskeletal elements on nuclear shape. In the long-term, we hope to understand the consequences of nuclear architecture to the variety of chromosomal functions.

Nucleosomes: the chromatin subunits.

A darkfield electron micrograph of chromatin spilling out of a chicken erythrocyte nucleus in a low ionic strength buffer
A darkfield electron micrograph of chromatin spilling out of a chicken erythrocyte nucleus in a low ionic strength buffer. Stained with uranyl acetate.

Publications. 

114.  Ada L. Olins, Gale Rhodes, David B. Mark Welch, Monika Zwerger and Donald E. Olins. (2010) Lamin B receptor: Multi-tasking at the nuclear envelope. Nucleus. 1:53-70. (FULL TEXT pdf)
113.  Donald E. Olins and Ada L. Olins. (2009)  Nuclear Envelope-Limited Chromatin Sheets (ELCS) and Heterochromatin Higher Order Structure. Chromosoma.  118:537-548. (FULL TEXT pdf)
112.  Ada L. Olins, Thanh V. Hoang, Monika Zwerger, Harald Herrmann, Hanswalter Zentgraf, Angelika A. Noegel, Iakowos Karakesisoglou, Didier Hodzic and Donald E. Olins. (2009)  The LINC-less granulocyte nucleus.  Eur. J. Cell Biol.  88:203-214.  (FULL TEXT pdf)
111.  Peter Gaines, Chiung Wen Tien, Ada L. Olins, Donald E. Olins, Leonard D. Shultz, Lisa Carny and Nancy Berliner. (2008)  Mouse neutrophils lacking lamin B receptor expression exhibit aberrant development and lack critical functional responses. Exp Hematol. 36(8):965-76.  (FULL TEXT pdf)
110.  Monika Zwerger, Harald Herrmann, Peter Gaines, Ada L. Olins, and Donald E.Olins. (2008) Granulocytic nuclear differentiation of lamin B receptor-deficient mouse EPRO cells.  Exp Hematol. 36(8):977-87.  (FULL TEXT pdf)
109.  Ada L. Olins, Monika Zwerger, Harald Herrmann, Hanswalter Zentgraf, Amos J. Simon, Marc Monestier, Donald E. Olins.  (2008)  The Human Granulocyte Nucleus: Unusual Nuclear Envelope and Heterochromatin Composition.  Eur J Cell Biol. 87(5):279-90.  (FULL TEXT pdf)
108.  Katrin Hoffmann, Karl Sperling, Ada L. Olins and Donald E. Olins. (2007)  The granulocyte nucleus and lamin B receptor: avoiding the ovoid. Chromosoma 116:227-235. (FULL TEXT pdf)
107.  Donald E. Olins and Ada L.Olins. (2005) Granulocyte Heterochromatin: Defining the Epigenome. BMC Cell Biology 2005, 6:39. (FULL TEXT pdf)
106.  Ada L. Olins and Donald E. Olins. (2005) The mechanism of granulocyte nuclear shape determination: possible involvement of the centrosome. Eur J Cell Biol 84: 181–188. (FULL TEXT pdf)
105.  Ada L. Olins and Donald E. Olins. (2004) Cytoskeletal influences on nuclear shape in granulocytic HL-60 cells. BMC Cell Biology 5:30. (FULL TEXT pdf)
104.  Donald E. Olins and Ada L. Olins. (2003) Chromatin history: our view from the bridge. Nat Rev Mol Cell Biol 4: 809-14. (FULL TEXT pdf)
103.  Leonard D. Shultz, Bonnie L. Lyons, Lisa M. Burzenski, Bruce Gott , Rebecca Samuels, Peter A.Schweitzer, Christine Dreger, Harald Herrmann, Vera Kalscheuer, Ada L. Olins, Donald E. Olins, Karl Sperling and Katrin Hoffman. (2003) Mutations at the Murine Ichthyosis Locus are within the Lamin B Receptor Gene: A Single Gene Model for Human Pelger-Huët Anomaly. Hum Mol Genet 12: 61-69. (FULL TEXT pdf)
102.  Hoffmann K, Dreger C, Olins AL, Olins DE, Shultz LD, Lucke B, Karl H, Kaps R, Mueller D, Vaya A, Aznar J, Ware R, Cruz NS, Lindner TH, Herrmann H, Reis A, Sperling K. (2002) Mutations in the Lamin B receptor gene produce an altered granulocyte nuclear morphology in humans (Pelger Huet Anomaly). Nature Genet 31: 410-414. (FULL TEXT pdf)
102.  Olins, A. L., Herrmann, H., Lichter, P., Kratzmeier, M., Doeneck, D., and Olins, D. E., (2001) Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells. Exp Cell Res 268: 115-127. (FULL TEXT pdf)
100.  Olins, A. L., Herrmann, H., Lichter, P., and Olins, D. E., (2000) Retinoic Acid Differentiation of HL-60 Cells Promotes Cytoskeletal Polarization. Exp Cell Res , 254: 130-142. (FULL TEXT pdf)
99.  Olins, A. L., Buendia, B., Herrmann, H., Lichter, P., and Olins, D. E., (1998) Retinoic Acid Induction of Nuclear Envelope-limited Chromatin Sheets in HL-60. Exp Cell Res , 245: 91-104. (FULL TEXT pdf)
98.  Shuster, M., Dhar, M. S., Olins, A. L., Olins, D. E., Howell, C., Gollin, S. M., and Chaillet, J. R., (1998) Parental Alleles of an Imprinted Mouse Transgene Replicate Synchronously. Dev Genet, 23: 275-284.  (FULL TEXT pdf)
97.  Olins, A. L., Olins, D. E., and Bazett-Jones D. P. (1996) Osmium Ammine-B and Electron Spectroscopic Imaging of Ribonuclear Proteins: Correlation of Stain and Phosphorus.  Biol Cell  87: 143-147.  (FULL TEXT pdf)
96.  Olins, D. E., (1995) The Replication Band of Euplotes is DNAse Sensitive.  Biol Cell, 83: 185-189. 
95.  Hauser L. J., Dhar, M. S., and Olins, D. E., (1995) Dictyostelium discoideum contains a single-copy gene encoding a unique subtype of histone H1. Gene, 154: 119-22.  (FULL TEXT pdf)
94.  Simon, I. and Olins, D.E., (1994)  Higher OrderAssociation of Extrachromosomal rDNA Genes in Dictyostelium discoideum . Cell Biol Int, 18: 1091-1094.  (FULL TEXT pdf)
93.  Olins, D. E., Cacheiro, L. H., and Herrmann, A., (1994) The Replication Band of Euplotesis Enriched with Phosphoproteins.  Biol Cell, 8: 237-246.
92.  Olins, D. E., and Olins, A. L. (1994) The replication of ciliated protozoa. Int. Rev. Cytol., 153: 137-170.
91.  Olins, A. L., Olins, D. E., Olman, V., Levy, H. A., and Bazett-Jones D. P. (1994)  Modeling the 3-D RNA distribution in the Balbiani Ring granule. Chromosoma, 103: 302-310.  (FULL TEXT pdf)
90.  Olins, A. L., D. E. Olins, H. A. Levy, M. B. Shah, and D. P. Bazett-Jones (1993) Electron microscope tomography of balbiani ring hnRNP substructure. Chromosoma, 102, 137-144.  (FULL TEXT pdf)
89.  Olins, A. L., and Olins, D. E.  (1993)  Stereo-electron microscopy of DNA-stained mitotic chromosomes from Dictyostelium discoideum, Cell Biol. International, 17: 941-944.  (FULL TEXT pdf)
88.  Hauser, L. J., Treat, M. L., and Olins, D. E., (1993) Cloning and analysis of the macronuclear gene for histone H1 from Euplotes eurystomus. Nucleic Acids Res, 21: 3586.  (FULL TEXT pdf)
87.  Olins, D. E., and Olins, A. L., (1993) Inhibition of DNA synthesis in the macronuclear replication band of euplotes eurystomus. J. Eukaryotic Microbiol. 40: 459-467.  (FULL TEXT pdf)
86.  Olins, A. L., Cacheiro, L. H., Herrmann, A. L.  Dhar, M. S., and Olins, D. E.  (1993)  Inaccessibility of the Euplotes Telomere Binding Protein, Chromosoma, 102: 700-711.  (FULL TEXT pdf)
85.  Olins, A. L. (1993) Application of a DNA Specific Stain, Osmium Ammine B, to Cellular Specimens. In:  Procedures in Electron Microscopy (A. W. Robards and A. J. Wilson, eds.), John Wiley & Sons, Chichester, England. (FULL TEXT pdf)
84.  Levy, H. A., Olins, A. L., and Olins, D. E., (1992) Distribution of projection angles for single-axis-tilt electron microscope tomography of extended thin planar specimens.  J. Microsc., 165, 325-330. (FULL TEXT pdf)
83.  Olins, A. L., D. E. Olins, and D. P. Bazett-Jones (1992) Balbiani ring hnRNP substructure visualized by selective staining and electron spectroscopic imaging. J. Cell. Biol. 117, 483-491.  (FULL TEXT pdf)
81.  Hauser, L. J., Roberson, A. E., and Olins, D. E., (1991) Structure of the macronuclear polyubiquitin gene in Euplotes. Chromosoma, 100: 386-94.  (FULL TEXT pdf)
80.  Olins, D. E., Olins, A. L., Herrmann, A., Lin, R., Allis, C. D., and Robert-Nicoud, M.  (1991)  Localization of acetylated histone H4 in the macronucleus of EuplotesChromosoma 100: 377-385.  (FULL TEXT pdf)
79.  Olins, A. L. and D. E. Olins (1990) Regular 10 nm filaments in the macronucleus of Euplotes eurystomusChromosoma 99, 205-211. 
78.  Yeh, E., R. Driscoll, M. Coltrera, A. Olins, and K. Bloom (1991) A dynamin-like protein encoded by the yeast sporulation gene SPO15.  Nature 349: 713-715.  (FULL TEXT pdf)
77.  Olins, A.L., B. A. Moyer, S.-H. Kim, and D. P. Allison (1989) A modified synthesis of a more stable osmium ammine, electron dense DNA stain. J. Histochem. Cytochem. 37, 395-39.  (FULL TEXT pdf)
76.  Colliex, C., C. Mory, A. L. Olins, D. E. Olins, and M. Tence (1989) Energy filtered STEM imaging of thick biological sections. J. Microsc. 153, 1-21.  (FULL TEXT pdf)
75.  Olins, A. L., D. E. Olins, H. A. Levy, S. M. Margle, E. P. Tinnel, and R. C. Durfee (1989) Tomographic reconstruction from energy filtered images of thick biological sections.  J. Microsc. 154, 257-265.  (FULL TEXT pdf)
74.  Kim, S.-H., B. A. Moyer, S. Azan, G. M.  Brown, A. L.  Olins  and D. P. Allison (1989) Preparation and properties of the nitrido-bridged osmium(IV) binuclear complexes   [OsIV2N(NH3)10-nCln]Cl5-n (n = 2,3).  Inorg. Chem. 28, 4648-4650.  (FULL TEXT pdf)
73.  Olins, D. E., A. L. Olins, M. Robert-Nicoud, T. M. Jovin, J. Wehland and K. Weber (1989) Differential distribution of a-tubulin isotypes in Euplotes eurystomus determined by confocal immunofluorescence microscopy.  Biol  Cell,  66, 235-246.  (FULL TEXT pdf)
72.  Olins, A. L., A. Herrmann, K. Weber, and D.E. Olins, (1989) Telomeric Proteins are related to Intermediate Filaments in Euplotes.   J Cell Biol. 108: 317a
71.  Olins, D. E., A. L. Olins, L. H. Cacheiro and E. M. Tan (1989) PCNA/cyclin in the ciliate Euplotes eurystomus:  localization in the replication band and in micronuclei.  J. Cell Biol. 109, 1399‑1410.  (FULL TEXT pdf)
70.  Roberson, A. E., A. P. Wolffe, L. J. Hauser, and D. E. Olins (1989) The 5S RNA Gene Minichromosome of Euplotes.  Nucleic Acids Res. 17: 4699-4712.  (FULL TEXT pdf)
69.  Olins, D. E., A. L. Olins, A.-P. Seve, C. A. Bourgeois, J. Hubert and M. Monsigny (1988) Lectin-like components in the macronuclear replication bands of Euplotes eurystomusBiol Cell,  62, 95-98, cover.  (FULL TEXT pdf)
68.  Olins, A. L., D. E. Olins, M. Derenzini, D. Hernandez-Verdun, P. Gounon, M. Robert-Nicoud, and T. M. Jovin (1988) Replication bands and nucleoli in the macronucleus of Euplotes eurystomus -An ultrastructural and cytochemical study.  Biol Cell, 62, 83-93.  (FULL TEXT pdf)
67.  Olins, D. E., and Olins, A. L., (1987) In vitro DNA synthesis in the macronuclear replication band of Euplotes eurystomus. J. Cell Biol. 104, 1125-1132, cover.  (FULL TEXT pdf)
66.  Herrmann, A. L., Cadilla, C. L., Cacheiro, L. H., Carne, A. F., and Olins, D. E., (1987) An H1-like protein from the macronucleus of Euplotes eurystomus. Eur J Cell Biol, 43: 155-62.
65.  Levy, H. A., S. M. Margle, E. P. Tinnel, R. C. Durfee, D. E. Olins, and A. L. Olins (1987) The varifocal mirror for 3-D display of electron microscope tomography.  J. Microsc. 145, 179‑190. (FULL TEXT pdf)
64.  Cadilla, C. L., A. E. Roberson, J. Harp, A. L. Olins, and D. E. Olins (1986) Subfractionation of soluble macronuclear chromatin and enrichment of specific genes as chromatin from Euplotes eurystomus.  Nucleic Acids Res. 14, 8501-8512.  (FULL TEXT pdf)
63.  Olins, A. L., D. E. Olins, H. A. Levy, R. C. Durfee, S. M. Margle, and E. P. Tinnel (1986) DNA compaction during intense transcription measured by electron microscope tomography.  Eur. J. Cell Biol. 40, 105-110. (FULL TEXT pdf)
62.  Cadilla, C. L., J. Harp, J. M. Flanagan, A. L. Olins, and D. E. Olins (1986) Preparation and characterization of soluble macronuclear chromatin from the hypotrich Euplotes eurystomus. Nucleic Acids Res. 14, 823-841.  (FULL TEXT pdf)
61.  Allen, R. L., S. J. Kennel, L. Cacheiro, A. L. Olins, and D. E. Olins (1986) Characterization of the macronuclear replication band in Euplotes eurystomus with monoclonal antibodies.  J. Cell Biol. 102, 131-136.  (FULL TEXT pdf)
60.  Allen, R. L., A. L. Olins, J. M. Harp, and D. E. Olins (1985) Isolation and characterization of chromatin replication bands and macronuclei from Euplotes eurystomus.  Eur. J. Cell Biol. 39, 217-223. (FULL TEXT pdf)
59.  Butler, A. P., Mardian, J. K., Olins, D. E., (1985) Nonhistone chromosomal protein HMG 1 interactions with DNA. Fluorescence and thermal denaturation studies. J Biol Chem, 260: 10613-20.  (FULL TEXT pdf)
58.  Olins, A. L., D. E. Olins, H. A. Levy, R. C. Durfee, S. M. Margle, E. P. Tinnel, B. E. Hingerty, S. D. Dover, and H. Fuchs (1984) Modeling Balbiani Ring gene transcription with electron microscope tomography.  Eur. J. Cell Biol. 35, 129-142, cover 37. (FULL TEXT pdf)
57.  Butler, A. P., Laughlin, T. J., Cadilla, C. L., Henry, J.M. , and Olins, D. E., (1984) Physical structure of gene-sized chromatin from the protozoan Oxytricha. Nucleic Acids Res, 12: 3201-17.  (FULL TEXT pdf)
56.  Laughlin, T. J., Herrmann, A. L., and Olins, D. E., (1984) Fractionation of the gene-size macronuclear chromatin fragments of the binucleated eukaryote Oxytricha. Mol Cell Biochem, 62: 157-163.  (FULL TEXT pdf)
55.  Allen, R. L., and Olins, D. E., (1984) Cytochemistry of the chromatin replication band in hypotrichous ciliated protozoa staining with silver and thiol-specific coumarin maleimide. Chromosoma, 91: 82-6.  (FULL TEXT pdf)
54.  Uberbacher, E. C., Ramakrishnan, V., Olins, D. E., and Bunick, G. J., (1983) Neutron scattering studies of nucleosome structure at low ionic strength. Biochemistry, 22: 4916-23.  (FULL TEXT pdf)
53.  Olins, A. L., and Olins, D. E., (1983) This Week's Citation Classic.  Current Contents, March 7, p. 25.
52.  Paton, A. E., Wilkinson-Singley, E., and Olins, D. E., (1983) Nonhistone nuclear high mobility group proteins 14 and 17 stabilize nucleosome core particles. J Biol Chem, 258: 13221-9.  (FULL TEXT pdf)
51.  Olins, D. E., A. L. Olins, H. A. Levy, R. C. Durfee, S. M. Margle, E. P. Tinnel, and S. D. Dover (1983) Electron microscope tomography: Transcription in 3-D. Science 220, 498-500, cover.  (FULL TEXT pdf)
50.  Butler, A. P. and Olins, D. E., (1982) pH Effects on the Structure of the Inner Histones. Biochimica et Biocphysica Acta 698:190-203.  (FULL TEXT pdf)
49.  Laughlin, T. J., E. Wilkinson-Singley, D. E. Olins, and A. L. Olins (1982) Stereo-electron microscope studies of mitotic chromosomes from Chinese hamster ovary cells.  Eur. J. Cell Biol. 27, 170-176. (FULL TEXT pdf)
48.  Olins, A. L., D. E. Olins, and M. Lezzi (1982) Ultrastructural studies of Chironomus salivary gland cells in different states of Balbiani ring activity.  Eur. J. Cell Biol. 27, 161-169. (FULL TEXT pdf)
47.  Uberbacher, E. C., Mardian, J. K., Rossi, R. M., Olins, D. E., and Bunick, G. J., (1982) Neutron scattering studies and modeling of high mobility group 14 core nucleosome complex. Proc Natl Acad Sci U S A, 79: 5258-5262.  (FULL TEXT pdf)
46.  Olins, A. L. (1982) Chromosomal and Nonchromosomal DNA:  A Summary and Perspective.  In: Molecular and Cellular Mechanisms of Mutagenesis, (J. F. .Lemontt and W. M. Generoso, eds.), Plenum Press, New York.
45.  Olins, A. L., D. E. Olins, W. W. Franke, H. J. Lipps, and D. M. Prescott (1981) Stereo-electron microscopy of nuclear structure and replication in ciliated protozoa (Hypotricha).  Eur. J. Cell Biol. 25, 120-130. (FULL TEXT pdf)
44.  Olins, A. L., D. E. Olins, and W. W. Franke (1980) Stereo-electron microscopy of nucleoli, Balbiani rings and endoplasmic reticulum in Chironomus salivary gland cells.  Eur. J. Cell Biol. 22, 714‑723. (FULL TEXT pdf)
43.  Olins, A. L., D. E. Olins, H. Zentgraf, and W. W. Franke (1980) Visualization of nucleosomes in thin sections by stereo-electron microscopy.  J. Cell Biol. 87, 833-836.  (FULL TEXT pdf)
42.  Mardian, J. K. W., A.E. Paton, G. J. Bunick, and D.E.Olins (1980) Nucleosome Cores have Two Specific Binding Sites for Nonhistone Chromosomal Proteins HMG 14 and HMG 17.  Science  209: 1534-1536.  (FULL TEXT pdf)
41.  Kootstra, A., Slaga, T. J., and Olins, D. E., (1979) Interaction of benzo[alpha]pyrene diol-epoxide with nuclei and isolated chromatin. Chem Biol Interact, 28: 225-36
40.  Olins, D. E. (1979) Conformational States of Nucleosomes.  In:  Chromatin Structure and Function, Part A:  Molecular and Cellular Biophysical Methods (as Vol. 21a in the NATO Advanced Study Institutes Life Science Series) (C. A. Nicolini, ed.).  Plenum Publishing Corp., pp. 41-48.
39.  Olins, A. L. (1979) Electron microscopy:  A tool for visualizing chromatin.  In:  Chromatin Structure and Function, Part A:  Molecular and Cellular Biophysical Methods (as Vol. 21a in the NATO Advanced Study Institutes Life Science Series) (C. A. Nicolini, ed.).  Plenum Publishing Corp., pp.31-40.
38.  Olins, A. L., E. Wilkinson-Singley, J. Bentley, and D. E. Olins (1979) Stereo-electron microscopy and energy-dispersive X-ray analysis of avian reticulocytes.  Eur. J. Cell Biol. 19: 239-249.
37.  Gordon, V. C., Schumaker, V. N., Olins, D. E., Knobler, C. M., and Horwitz, J., (1979) The temperature and pH dependence of conformational transitions of the chromati subunit. Nucleic Acids Res, 6: 3845-58.  (FULL TEXT pdf)
36.  Butler, A. P., Harrington, R. E., and Olins, D. E., (1979) Salt-dependent interconversion of inner histone oligomers. Nucleic Acids Res,  6: 1509-20.  (FULL TEXT pdf)
35.  Bryan, P. N., Wright, E. B., and Olins, D. E., (1979) Core nucleosomes by digestion of reconstructed histone-DNA complexes. Nucleic Acids Res, 6: 1449-65.  (FULL TEXT pdf)
34.  Olins, A. L., and D. E. Olins (1979) Stereo electron microscopy of the 25-mm chromatin fibers in isolated nuclei.  J. Cell Biol. 81: 260-265.  (FULL TEXT pdf)
33.  Olins, D. E., (1978) Internal and higher-order structure of chromatin nu bodies. Molecular human cytogenetics, pp. 1-16.
32.  Gordon, V. C., Knobler, C. M., Olins, D.E., and Schumaker, V. N., (1978) Conformational changes of the chromatin subunit. Proc Natl Acad Sci U S A, 75: 660-3.  (FULL TEXT pdf)
31.  Olins, D. E., and A. L. Olins (1978) Nucleosomes:  The structural quantum in chromosomes.  American Scientist 66: 704-711.
30.  Zama, M., Olins, D. E., Prescott, B., and Thomas, G. J. Jr (1978) Nucleosome conformation: pH and organic solvent effects. Nucleic Acids Res, 5: 3881-97.  (FULL TEXT pdf)
29.  Bryan, P. N., E. B. Wright, M. H. Hsie, A. L. Olins, and D. E. Olins (1978) Physical properties of inner histone-DNA complexes.  Nucleic Acid Res. 5: 3603-3617.  (FULL TEXT pdf)
28.  Zama, M., D. E. Olins, E. Wilkinson-Singley, and A. L. Olins (1978) Reversibility of nucleosome conformation perturbed by urea.  Biochem. Biophys. Res. Comm. 85: 1446-1451.  (FULL TEXT pdf)
27.  Olins, A. L. (1978) Nu-bodies are close-packed in chromatin.  Cold Spring Harbor Symp. Quant. Biol. XLII: 325-329.
26.  Zama, M., P. N. Bryan, R. E. Harrington, A. L. Olins, and D. E. Olins (1978) Conformational states of chromatin.  Cold Spring Harbor Symp. Quant. Biol. XLII, 31-41
26a.  Olins, A. L. (1978) Visualization of chromatin nu bodies.  In:  Methods in Cell Biology, Vol. 18 (G. Stein, J. Stein, and L. Kleinsmith, eds.), Academic Press, New York, pp. 61-68.
25.  Olins, A. L., J. P. Breillat, R. D. Carlson, M. B. Senior, E. B. Wright, and D. E. Olins (1977) On nu models for chromatin structure.  In:  The Molecular Biology of the Mammalian Genetic Apparatus, Part A. (P. O. P. Tso, ed.), Elsevier/North Holland Biomedical Press, Amsterdam, pp. 211-237. (FULL TEXT pdf)
24.  Thomas GJ Jr, Prescott B. and Olins, D.E. (1977) Secondary structure of histones and DNA in chromatin. Science 197: 385-8.  (FULL TEXT pdf)
23.  Olins, D. E., P. N. Bryan, R. E. Harrington, W. E. Hill, and A. L. Olins (1977) Conformational states of chromatin nu bodies induced by urea.  Nucleic Acid Res. 4: 1911-1931.  (FULL TEXT pdf)
22.  Olins, A. L., R. D. Carlson, E. B. Wright, and D. E. Olins (1976) Chromatin nu bodies:  Isolation, subfractionation and physical characterization.  Nucleic Acids Res. 3: 3271-3291.  (FULL TEXT pdf)
21.  Carlson, R. D., and Olins, D. E., (1976) Chromatin model calculations: Arrays of spherical nu bodies. Nucleic Acids Res, 3: 89-100.  (FULL TEXT pdf)
20.  Olins, A. L., M. B. Senior, and D. E. Olins (1976) Ultrastructural features of chromatin nu bodies.  J. Cell Biol. 68: 787-792.  (FULL TEXT pdf)
19. Howze, G. B., A. W. Hsie, and A. L. Olins (1976) Nu bodies in mitotic chromatin.  Exp. Cell Res. 100: 424-428.  (FULL TEXT pdf)
18.  Senior, M. B., Olins, A. L. and Olins, D. E., (1975) Chromatin fragments resembling nu bodies. Science 187: 173-175.  (FULL TEXT pdf)
17.  Senior, M. B, and Olins, D. E., (1975) Effect of formaldehyde on the circular dichroism of chicken erythrocyte chromatin. Biochemistry, 14: 3332-3337.  (FULL TEXT pdf)
16.  Carlson, R. D., A. L. Olins, and D. E. Olins (1975) Urea denaturation of chromatin periodic structure.  Biochemistry 14: 3122-3125.  (FULL TEXT pdf)
15.  Wright, E. B., and Olins, D. E. (1975) Histone stoichiometry in chicken erythrocyte nuclei. Biochem Biophys Res Commun, 63: 642-50.  (FULL TEXT pdf)
14.  Olins, A. L., Carlson, R. D., and Olins, D. E., (1975) Visualization of chromatin substructure - nu bodies.  J. Cell Biol. 64: 528-537.  (FULL TEXT pdf)
13.  Olins, A. L., and D. E. Olins (1974) Spheroid chromatin units (nu bodies). Science 183: 330-332.  (FULL TEXT pdf)
12.  Sheehan, D. M., and Olins, D. E., (1974) The binding of nuclear non-histone protein to DNA. Biochim Biophys Acta  353: 438-46.  (FULL TEXT pdf)
11.  Olins, D. E., and Wright E. B.,( 1973) Glutaraldehyde fixation of isolated eucaryotic nuclei. Evidence for histone-histone proximity. J Cell Biol , 59:304-17.  (FULL TEXT pdf)
10.  Olins, D. E., and A. L. Olins (1972) Physical studies of isolated eucaryotic nuclei.  J. Cell Biol. 53: 715-736.  (FULL TEXT pdf)
9.  Olins, D. E., and Olins,A. L., (1971) Model nucleohistones:  The interaction of F1 and F2a1 histones with native T7 DNA.  J. Mol. Biol. 57: 437-455.  (FULL TEXT pdf)
8.  Olins, D. E., (1969) Interaction of lysine-rich histones and DNA. J Mol Biol, 43:439-60.  (FULL TEXT pdf)
7.  Olins, D. E., Olins, A. L., and von Hippel, P. H., (1968) On the structure and stability of DNA-protamine and DNA-polypeptide complexes.  J. Mol. Biol. 33: 265-281.  (FULL TEXT pdf)
6.  Olins, D. E., Olins, A. L., and von Hippel, P. H., (1967) Model nucleoprotein complexes:  Studies on the interaction of cationic homopolypeptides with DNA.   J. Mol. Biol. 24: 157-176.  (FULL TEXT pdf)
5.  Olins, A. L., and R. C. Warner (1967) Physicochemical studies on a lipopolysaccharide from the cell wall of Azotobacter vinlandiiJ. Biol. Chem. 242: 4994-5001.  (FULL TEXT pdf)
4.  Fougereau, M., D.E. Olins and G.M.Edelman (1964) Reconstitution of Antiphage Antibodies from L and H Polypeptide Chains and the formation ofInterspecies Molecular Hybrids.  J.  Exp. Med. 120: 349-358.  (FULL TEXT pdf)
3.  D. E. Olins and G. M. Edelman, (1964) Reconstitution of 7S Molecules from L and H Polypeptide Chaines of Antibodies and g-Globulins. .J. Exp. Med. 119: 789-815.  (FULL TEXT pdf)
2.  G. M. Edelman, D. E. Olins, J. A. Gally, and N. D. ZINDER (1963) Reconstitution Of Immunologic Activity By Interaction of Polypeptide Chains of Antibodies. PNAS 50: 753-761.  (FULL TEXT pdf)
1.  D. E. Olins and G. M. Edelman, (1962) The Antigenic Structure Of The Polypeptide Chains Of Human g-Globulin. J Exp Med 116: 635-651.  (FULL TEXT pdf)