Anja Forche

Research Assistant Professor

Phone (207) 725-3365
Title Research Assistant Professor
Department Biology
Work Location 014 Hatch Science Building
E-Mail aforche@bowdoin.edu

Education

PhD, Technical University Berlin, Germany

Current Research Topics

Genome integrity in Candida albicans, Host-pathogen interactions in vivo

Publications

Gräser, Y., Tietz, H.-J., Vilgalys, R., Mitchell, T.G., Forche, A., Presber, W., Schönian, G. 1997. Detection and application of DNA polymorphisms to identify species and strains of Candida and to analyze the population structure of Candida albicans. Microbiological Culture Collection 13: 11-20

Forche, A., Schönian, G., Gräser, Y., Vilgalys, R., Mitchell, T. G. 1999. Genetic structure of typical and atypical populations of Candida albicans from Africa. Fungal Genetics and Biology 28: 107-125

Pinto de Adrade, M., Schoenian, G., Forche, A., Rosado, L., Costa,I., Mueller, M., Presber, W., Mitchell, T. G., Tietz, H.-J. 2000. Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins. International Journal of Medical Microbiology 290: 97-104.

Schönian, G., Forche, A., Tietz, H. J., Muller, M., Graeser, Y., Vilgalys, R., Mitchell, T. G., Presber, W. 2000. Genetic structure of geographically different populations of Candida albicans. Mycoses 43: 51-56

Forche, A., Xu, J., Vilgalys, R. Mitchell, T.G. 2001. Development and Characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers. Fungal Genetics and Biology 31: 189-203.

Forche, A. May, G., Beckerman, J., Kauffman, S., Becker, J., Magee, P.T. 2003. A System for studying genetic changes in Candida albicans during infection. Fungal Genetics and Biology, 39: 38-50.

Forche, A., Magee, P. T., Magee, B. B., May, G. 2004. Development of a genome-wide SNP map for Candida albicans 2004. Eukaryotic Cell, 3: 705-714.

Forche, A., May, G., and P. T. Magee 2005. Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection. Eukaryotic Cell 4: 156-165.

Coste, A., Turner, V., Ischer, F., Morschhauser, J., Forche, A., Selmecki, A., Berman, J., Bille, J., Sanglard, D. 2006. A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. Genetics 172: 2139-2156.

Selmecki, A., Forche, A., and Berman, J. 2006. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313: 367-370.

Coste, A., Selmecki, A., Forche, A., Diogo, D. Bougnoux, M. E., d’Enfert, C., Berman, J., Sanglard, D. 2007. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryotic Cell 6: 1889-1904.

Legrand, M., Forche, A., Selmecki, A., Chan, C., Kirkpatrick, D. T., Berman, J. 2008. Haplotype mapping of a diploid non-meiotic organism using existing and induced aneuploidies. PloS Genetics 4: 18-28.

Forche, A., Alby, K., Schaefer, D., Johnson, A. D., Berman, J., Bennett, R. J. 2008. The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol. 2008 May 6;6(5):e110.

Selmecki, A., Gerami-Nejad, M., Paulson, C., Forche, A., Berman, J. 2008. Two genes, amplified on an isochromosome, confer drug resistance in vivo by independent mechanisms. Mol Microbiol. 2008 May;68(3):624-41.

Forche, A., Selmecki, A., Magee, P. T., Berman, J., May, G. (2009). Evolution in Candida albicans populations during a single passage through a mouse host. Genetics 182: 799-811.

Butler, G. et al. (2009). Evolution of pathogenicity and sexual reproduction in eight Candida Genomes. Nature 459: 657-662.

Forche, A., Steinbach, M, and Berman, J. (2009). Efficient and Rapid identification of Candida albicans allelic status using SNP-RFLP. FEMS Yeast Res. Epub ahead of print.

Bouchonville, K., Forche, A. Tang, K. E., Selmecki, A., Berman, J. (2009). Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans. Eukaryotic Cell 8(10):1554-66