Location: Bowdoin / aforche

Biology

Anja Forche

Research Assistant Professor

Contact Information

aforche@bowdoin.edu
207-725-3365
Biology
13 Hatch Science Building




Anja Forche Bowdoin College: Biology

Education

  • PhD, Technical University Berlin, Germany

Current Research Topics

  • Genome integrity in Candida albicans, Host-pathogen interactions in vivo

 

Gräser, Y., Tietz, H.-J., Vilgalys, R., Mitchell, T.G., Forche, A., Presber, W., Schönian, G. 1997. Detection and application of DNA polymorphisms to identify species and strains of Candida and to analyze the population structure of Candida albicans. Microbiological Culture Collection 13: 11-20

Forche, A., Schönian, G., Gräser, Y., Vilgalys, R., Mitchell, T. G. 1999. Genetic structure of typical and atypical populations of Candida albicans from Africa. Fungal Genetics and Biology 28: 107-125

Pinto de Adrade, M., Schoenian, G., Forche, A., Rosado, L., Costa,I., Mueller, M., Presber, W., Mitchell, T. G., Tietz, H.-J. 2000. Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins. International Journal of Medical Microbiology 290: 97-104.

Schönian, G., Forche, A., Tietz, H. J., Muller, M., Graeser, Y., Vilgalys, R., Mitchell, T. G., Presber, W. 2000. Genetic structure of geographically different populations of Candida albicans. Mycoses 43: 51-56

Forche, A., Xu, J., Vilgalys, R. Mitchell, T.G. 2001. Development and Characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers. Fungal Genetics and Biology 31: 189-203.

Forche, A. May, G., Beckerman, J., Kauffman, S., Becker, J., Magee, P.T. 2003. A System for studying genetic changes in Candida albicans during infection. Fungal Genetics and Biology, 39: 38-50.

Forche, A., Magee, P. T., Magee, B. B., May, G. 2004. Development of a genome-wide SNP map for Candida albicans 2004. Eukaryotic Cell, 3: 705-714.

Forche, A., May, G., and P. T. Magee 2005. Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection. Eukaryotic Cell 4: 156-165.

Coste, A., Turner, V., Ischer, F., Morschhauser, J., Forche, A., Selmecki, A., Berman, J., Bille, J., Sanglard, D. 2006. A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. Genetics 172: 2139-2156.

Selmecki, A., Forche, A., and Berman, J. 2006. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313: 367-370.

Coste, A., Selmecki, A., Forche, A., Diogo, D. Bougnoux, M. E., d’Enfert, C., Berman, J., Sanglard, D. 2007. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryotic Cell 6: 1889-1904.

Legrand, M., Forche, A., Selmecki, A., Chan, C., Kirkpatrick, D. T., Berman, J. 2008. Haplotype mapping of a diploid non-meiotic organism using existing and induced aneuploidies. PloS Genetics 4: 18-28.

Forche, A., Alby, K., Schaefer, D., Johnson, A. D., Berman, J., Bennett, R. J. 2008. The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol. 2008 May 6;6(5):e110.

Selmecki, A., Gerami-Nejad, M., Paulson, C., Forche, A., Berman, J. 2008. Two genes, amplified on an isochromosome, confer drug resistance in vivo by independent mechanisms. Mol Microbiol. 2008 May;68(3):624-41.

Forche, A., Selmecki, A., Magee, P. T., Berman, J., May, G. (2009). Evolution in Candida albicans populations during a single passage through a mouse host. Genetics 182: 799-811.

Butler, G. et al. (2009). Evolution of pathogenicity and sexual reproduction in eight Candida Genomes. Nature 459: 657-662.

Forche, A., Steinbach, M, and Berman, J. (2009). Efficient and Rapid identification of Candida albicans allelic status using SNP-RFLP. FEMS Yeast Res. Epub ahead of print.

Bouchonville, K., Forche, A. Tang, K. E., Selmecki, A., Berman, J. (2009). Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans. Eukaryotic Cell 8(10):1554-66

Selmecki, A. M., Forche, A., Berman, J. (2010). Genomic Plasticity of the Human Fungal Pathogen Candida albicans. Eukaryotic Cell 9: 991-1008. PMID: 20495058

Forche, A., Abbey, D., Pisithkul, T., Weinzierl, M. A., Ringstrom, T., Bruck, D., Petersen K, Berman J. (2011) Stress alters rates and types of loss of heterozygosity in Candida albicans. Mbio, 2: e00129-11. PMID: 21791579 

Gerami-Nejad, M., Forche, A., McClellan, M., Berman, J. (2012). Analysis of protein function in clinical C. albicans isolates. Yeast 29: 303-309. PMID: 22777821 

Hickman, M. A., Zeng, G., Forche, A., Hirakawa, M. P., Abbey, D., Harrison, B. D., Wang, Y. M., Su, C. H., Bennett, R. J., Wang, Y., Berman, J.. (2013). The 'obligate diploid' Candida albicans forms mating-competent haploids. Nature 494: 55-59. PMID: 23364695

Undergraduate co-authors in bold

Candida Resources

The Candida Genome Database
http://www.candidagenome.org/

Saccharomyces Genome Database
http://www.yeastgenome.org/ 

The Physical map of Candida slbicans
http://albicansmap.ahc.umn.edu/

Fungi at the Broad Institute
http://www.broadinstitute.org/annotation/genome/candida_group/MultiHome.html

Search for research papers on PubMed
http://www.ncbi.nlm.nih.gov/pubmed/ 

Collaborators

Berman Lab at the University of Minnesota
http://www.cbs.umn.edu/labs/berman/

Berman Lab at Tel-Aviv University
http://www6.tau.ac.il/berman/

Filler Lab at UCLA
http://people.healthsciences.ucla.edu/institution/personnel?personnel_id=46596 

Wheeler lab at University of Maine, Orono
http://umaine.edu/biomed/faculty/robert-wheeler/ 

Dudley lab at the Institute for Systems Biology
https://www.systemsbiology.org/dudley-group 

Conferences

ASM Conference on Candida and Candidiasis
http://conferences.asm.org/index.php/upcoming-conferences/12th-asm-conference-on-candida-and-candidiasis 

Fungal Genetics Conference Asilomar
http://www.fungalgenetics.org/2013/

Gordon Research Conference on Cellular and Molecular Fungal Biology
http://www.grc.org/programs.aspx?year=2014&program=fungal

Experimental Approaches to Evolution and Ecology using Yeast & other Model Systems
http://www.embl.de/training/events/2014/EAE14-01/index.html 

Molecular Mechanisms of Host -Pathogen Interactions and Virulence - HFP2013
http://www.fems-microbiology.org/nc/repositories/events-calendar/detail.html?meeting=2244