Gregory A. Cox, Ph. D.
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609
PH (207) 288-6502
FX (207) 288-6073
Gregory A. Cox received his Bachelor of Science Degree in Biology (1989) from Humboldt State University in California and then moved on to earn a Ph.D. in Human Genetics from the University of Michigan in 1994. His thesis research focused on restoring muscle structure and function in transgenic mouse models of Duchenne muscular dystrophy. He arrived at The Jackson Laboratory at the end of 1994 to do his Postdoctoral training with Dr. Wayne Frankel studying the genetics of epilepsy and neuromuscular disorders. He started is own lab as an Associate Staff Scientist in 1999 and is currently an Associate Professor at JAX. Dr. Cox¹s research program is focused upon molecular pathways necessary for the normal function and survival of motor neurons and their skeletal muscle targets.
Selected Relevant Publications:
Mitsuhashi S, Ohkuma A, Talim B, Karahashi M, Koumura T, Aoyama C, Kurihara M, Quinlivan R, Sewry C, Mitsuhashi H, Goto K, Koksal B, Kale G, Ikeda K, Taguchi R, Noguchi S, Hayashi YK, Nonaka I, Sher RB, Sugimoto H, Nakagawa Y, Cox GA, Topaloglu H, Nishino I. A novel congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Am J Hum Gen 2011; 88:845-851.
Heiman-Patterson TD, Sher RB, Blankenhorn EA, Alexander G, Deitch JS, Kunst CB, Figlewicz D, Maragakis N, Cox GA. Effect of Genetic Background on Phenotype Variability in Transgenic Mouse Models of Amyotrophic Lateral Sclerosis: A window of opportunity in the search for genetic modifiers. Amyotroph Lateral Scler 2011; 12:79-86.
Mohamed JS, Lopez MA, Cox GA, Boriek AM. Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 2010; 24:3330-3340.
Burgess RW, Cox GA, Seburn KL. Neuromuscular disease models and analysis. Methods Mol Biol 2010; 602:347-393.
Wu G, Sher RB, Cox GA, Vance DE. Differential Expression of Choline Kinase Isoforms in Skeletal Muscle Explains the Phenotypic Variability in the Rostrocaudal Muscular Dystrophy Mouse. Biochim Biophys Acta 2010;
Lee BJ, Cox GA, Maddatu TP, Judex S, Rubin CT. Devastation of bone tissue in the appendicular skeleton parallels the progression of neuromuscular disease. J Musculoskelet Neuronal Interact 2009; 9:215-224.
Martinelli P, La Mattina V, Bernacchia A, Magnoni R, Cerri F, Cox G, Quattrini A, Casari G, Rugarli EI. Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. Hum Mol Genet 2009; 18:2001-2013.
Wu G, Sher RB, Cox GA, Vance DE. Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice. Biochim Biophys Acta 2009; 1791:347-356.
Lopez MA, Pardo P, Cox GA, Boriek AM. Early Mechanical Dysfunction of the Respiratory Pump in the Muscular Dystrophy with Myositis (Ttnmdm) Model. Am J Physiol Cell Physiol 2008; 295:C1092-1102.
Cohen TJ, Waddell DS, Barrientos T, Lu Z, Feng G, Cox GA, Bodine SC, Yao TP. The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem 2007; 282:33752-33759.